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Target intelligence / Profile preview
Shootin 1 (SHTN1)
- Target
- SHTN1
- Molecular classification
- Cytoplasmic protein, Microtubule-associated protein, Neuronal polarity regulator, Signaling regulator
01
Overview
Shootin 1 is a cytoplasmic protein that regulates neuronal polarization and neurite outgrowth by organizing cytoskeletal components (such as actin and microtubules) in the growth cone of developing neurons. It mediates signal transduction pathways triggered by netrin-1 and is crucial for converting cytoskeletal retrograde flow into forward traction, supporting axon extension and migration. Shootin 1 acts as a “clutch molecule” in axon growth cones, interacting with proteins such as CDC42, RAC1, and PAK1. It plays an essential role during neurodevelopment by facilitating the transition from multipolar to bipolar neuron morphology and guiding radial migration of cortical neurons. While some disease associations exist, Shootin 1 is not a therapeutic target, and there is currently no evidence of drugs or biomarkers involving Shootin 1 in clinical settings.
- Other names
- SHTN1KIAA1598shootin-1
02
Mechanism of action
Not applicable; no drugs target Shootin 1 directly
03
Biological functions
Neuronal polarizationNeurite outgrowthPositive regulation of neuron migrationCytoskeletal organizationF-actin–substrate coupling
04
Disease associations
Some association with brain cancers (e.g., extrahepatic bile duct adenocarcinoma, diencephalic astrocytoma)Nervous system development disorders (potential, based on function)Neurodevelopmental conditions (potential inference; not established as a biomarker or drug target)
05
Safety considerations
Not applicable; no clinical interventions target Shootin 1, so no safety data or therapeutic challenges reported
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