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Target intelligence / Profile preview
Short transmembrane mitochondrial protein 1 (STMP1)
- Target
- STMP1
- Molecular classification
- Microprotein, Transmembrane protein, Mitochondrial inner membrane protein
01
Overview
Short transmembrane mitochondrial protein 1 (STMP1), encoded by the *STMP1* gene, is a 47-amino acid microprotein localized to the inner mitochondrial membrane. It regulates the assembly and activity of respiratory chain complex III and supercomplexes, contributing to efficient mitochondrial electron transport and cellular energy production. It is cardiac-enriched but expressed across tissues and evolutionarily conserved from fish to mammals. STMP1 is homologous to mitolamban and is implicated in mitochondrial bioenergetics, cardiac stress response, inflammasome activation, and tumor cell metastasis. Dysregulation of STMP1 causes mitochondrial dysfunction and is implicated in diseases such as cardiomyopathy, cancer, and potentially neurodegeneration[2][3][6][7].
- Other names
- MitolambanC7orf73MtlbnMm47PL-5283uncharacterized protein C7orf73
02
Biological functions
Mitochondrial complex III assemblyMitochondrial respiratory supercomplex organizationMitochondrial cytochrome c oxidase assemblyRegulation of oxidative phosphorylationNLRP3 inflammasome activation (by similarity)Enhances mitochondrial fission (in cancer )
03
Disease associations
Cardiac disease (gene overexpression associated with cardiomyopathy in mice)Neurodegenerative diseases (defective sTM proteins implicated)Cancer (promotes tumor metastasis via mitochondrial fission)
04
Safety considerations
Potential cardiac toxicity: Overexpression associated with increased oxidative stress and premature death due to cardiomyopathy in mouse modelsMitochondrial dysfunction: Disruption can impair cellular respiration
05
Biomarkers
Not established as a clinical biomarker, but its expression correlates with cardiac stress/heart failure and cancer progression
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