Shortage in chiasmata 1 protein (SHOC1)

The Shortage in chiasmata 1 protein (SHOC1) is involved in the formation of crossovers (chiasmata) between homologous chromosomes during meiosis, especially in plants like Arabidopsis and potato. Loss-of-function mutations in SHOC1 impair crossover formation, leading to meiotic errors and reduced fertility. The SHOC1 orthologue's role appears to be conserved in meiotic recombination processes across some eukaryotes but is mainly studied in plant systems. SHOC1 is not considered a conventional pharmacological or therapeutic target and is instead a genetic factor relevant to studies of meiosis and plant breeding. In potato, a “crossover shortage” phenotype has been linked to mutations in genes such as StMSH4, not in SHOC1 itself. In animals and humans, SHOC1 is not a commonly referenced gene/protein, and there is no evidence for it being a therapeutic target or biomarker. If you are seeking information about "chiasma shortage" or "shortage of chiasmata" as a cytological phenomenon in meiosis, this refers to the reduced physical linkages (chiasmata) between homologous chromosomes, not a specific molecular target. In such contexts, proteins like SHOC1 or MSH4 may be involved in the underlying biology, especially in plants.

Other names

SHOC1shortage in chiasmata 1 orthologue

Not applicable as no drugs target this protein