Sialate:O-sulfotransferase 2 (WSCD2)

Sialate:O-sulfotransferase 2 (WSCD2) is a protein-coding enzyme located on human chromosome 12. It catalyzes the transfer of a sulfate group to the 8-O position of sialic acid residues within glycoproteins, prominently including transferrin. The enzyme uses 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a sulfate donor, resulting in formation of 8-O-sulfated Sia-glycans. WSCD2’s main molecular classification is as a sulfotransferase, and it is predicted to operate in the Golgi membrane. Although cataloged as associated with certain skin diseases and personality trait loci, there is no established role for WSCD2 as a therapeutic target, nor are there known drugs or safety concerns linked to this molecule as of 2025.

Other names

WSC domain containing 2Sialate:O-sulfotransferase 2WSCD2KIAA0789WSC domain-containing protein 2

If a drug were to target WSCD2, plausible mechanisms would be enzyme inhibition or modulation of glycan sulfation, but no drugs have been described with such mechanisms for this molecule. Actions would be expected to alter the level or pattern of 8-O-sulfated sialic acid glycans.