Sialic acid–binding immunoglobulin-type lectin 10 (Siglec-10)

Siglec-10 is an inhibitory receptor expressed on various immune cells, including B cells, monocytes, and dendritic cells. It recognizes sialylated glycans, particularly α2–3 or α2–6 linked sialic acids. Upon ligand binding, Siglec-10 recruits SHP phosphatases via its ITIM motifs, leading to the inhibition of immune cell activation. The CD24/Siglec-10 pathway is implicated in tumor immune evasion, making it a potential target for cancer immunotherapy. Soluble ligands like CD52 can also engage Siglec-10 to inhibit T-cell activation. Siglec-10 is a type I transmembrane protein with five extracellular immunoglobulin-like domains and two cytoplasmic ITIMs.

Other names

PRO940SLG2MGC126774sialic acid binding Ig like lectin 10

Ligand engagement recruits SHP phosphatases via ITIMs to dampen immune cell activation and signaling pathways such as NFATc1 and NF-kB in B cells through SHP1/Grb2 recruitment.