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Target intelligence / Profile preview
Sialic acid binding Ig-like lectin 3 (SIGLEC 3)
- Target
- SIGLEC 3
- Molecular classification
- Siglec family, CD33-related Siglecs, Immunoglobulin superfamily, Type I transmembrane protein, Lectins
01
Overview
Sialic acid-binding Ig-like lectin 3 (SIGLEC3), also known as CD33, is a transmembrane receptor primarily expressed on myeloid cells. It functions as an inhibitory receptor by binding to sialic acids and recruiting phosphatases to its ITIMs, leading to reduced immune cell activation. It is a key marker for Acute Myeloid Leukemia.
- Other names
- CD33gp67p67
02
Mechanism of action
Recruitment of SH2-domain-containing phosphatases (SHP-1, SHP-2) to ITIMs, leading to dephosphorylation of signaling molecules and inhibition of cellular activation.
03
Biological functions
Immune regulationInhibition of cell activationSignal transductionNegative regulation of phagocytosisModulation of inflammatory responses
04
Disease associations
Acute Myeloid LeukemiaInflammation
05
Biomarkers
CD33 expression level in AML blasts
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