Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Sialic acid-binding Ig-like lectin 8 (Siglec-8)
- Target
- Siglec-8
- Molecular classification
- Receptor, Type I transmembrane protein, CD33-related siglec, Lectin
01
Overview
Siglec-8 is a member of the CD33-related Siglec family, selectively expressed on eosinophils and mast cells. It functions as an inhibitory receptor, and its engagement induces apoptosis in eosinophils through a signaling cascade involving SFKs, Syk, SHIP1, PAK1, MEK1/ERK1/2, PLC/PKC, acid sphingomyelinase/ceramidase, and Btk. Siglec-8 is a therapeutic target for diseases involving eosinophil accumulation/activation, such as asthma and hypereosinophilic syndromes.
02
Mechanism of action
Monoclonal antibodies targeting Siglec-8 induce eosinophil depletion/inhibition via apoptosis.
03
Biological functions
Inhibitory receptor signalingImmunoregulationApoptosisCell deathInnate immunityAntigen processing/presentation
04
Disease associations
Eosinophilic gastritisChronic inducible urticariaAsthmaChronic rhinosinusitis with nasal polypsHypereosinophilic syndromes
05
Safety considerations
Potential for broad immune suppression due to Siglec-8's role in immune regulation.Off-target effects due to potential expression on other immune cell types (though expression is highly restricted).
Beyond the preview
Go deeper on Sialic acid-binding Ig-like lectin 8 (Siglec-8).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Sialic acid-binding Ig-like lectin 8 (Siglec-8).