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Target intelligence / Profile preview
Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15)
- Target
- Siglec-15
- Molecular classification
- Immunoglobulin superfamily, Siglecs, Type I transmembrane protein, Lectins
01
Overview
Siglec-15 is an emerging glycoimmune checkpoint molecule involved both in modulating antitumor immunity and regulating bone homeostasis through its effects on myeloid lineage cells. Its unique structure/function profile makes it a promising therapeutic target across oncology and metabolic bone diseases.
- Other names
- SIGLEC15
02
Mechanism of action
Blockade of Siglec-15 enhances anti-tumor immunity and suppresses antigen-specific T cell proliferation.
03
Biological functions
Immune suppressionImmune checkpointRegulation of T cell responseRegulation of osteoclastogenesisSignal transduction
04
Disease associations
CancerBone metastasisOsteopetrosisOsteolytic activity
05
Safety considerations
Potential for immune-related adverse eventsPotential for affecting bone homeostasis
06
Biomarkers
Siglec-15 expression level
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