Sialic acid binding immunoglobulin-like lectin 17 pseudogene (SIGLEC17P)

SIGLEC17P is a pseudogene located on chromosome 19 that belongs to the sialic acid-binding immunoglobulin-like lectin (Siglec) family[1][3]. While it is a non-functional pseudogene that does not encode protein, it was originally a functional gene (SIGLEC17) that was inactivated by a single base pair deletion during human evolution after our divergence from chimpanzees[9]. The pseudogene mRNA is still expressed at high levels in human natural killer cells[9]. In lung adenocarcinoma research, SIGLEC17P has emerged as a significant player, with low expression observed in tumor tissues compared to normal tissue[1]. The pseudogene appears to have antioncogenic effects, as overexpression inhibits proliferation, migration, and invasion of lung cancer cells through regulatory mechanisms involving specific microRNA pathways[1]. SIGLEC17P serves as both a diagnostic biomarker and independent prognostic factor for lung adenocarcinoma, with expression levels associated with advanced tumor stages[1]. The gene has multiple transcript variants but produces no protein product[3].

Other names

HSPC078SIGLECP2SIGLECP3

Regulatory mechanisms involving microRNA pathways (mir-20-3p/ADH1B and mir-4476-5p/DPYSL axes), though as a pseudogene it does not produce functional protein