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Sialic Acid Biosynthesis Pathway
- Molecular classification
- Metabolic Pathway
01
Overview
The sialic acid biosynthesis pathway is a conserved metabolic route in animals and some microorganisms responsible for the production of sialic acids, a family of nine-carbon acidic monosaccharides. The most common form in humans is N-acetylneuraminic acid (Neu5Ac). Sialic acids are typically found at the terminal positions of glycan chains on glycoproteins and glycolipids, playing crucial roles in cell-cell interaction, immune response modulation, pathogen recognition, and cancer progression.
02
Biological functions
GlycosylationBiosynthesis of Sialic AcidsImmune modulationCell adhesionPathogen binding regulationRegulation of signaling pathways
03
Disease associations
Congenital disorders of glycosylationCancer metastasisImmune disorders
04
Safety considerations
Dysregulation can lead to disorders such as hereditary inclusion body myopathy
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