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Target intelligence / Profile preview
Sialic Acid-Containing Receptor (Sia Receptor)
- Target
- Sia Receptor
- Molecular classification
- Glycoprotein, Glycolipid, Receptor
01
Overview
Sialic acid-containing receptors are glycan structures present on the surface of vertebrate cells, most abundantly at the terminal positions of glycoproteins and glycolipids. They mediate cell–cell interactions, modulate immune responses via interactions with Siglecs, and serve as attachment points for various pathogens, including viruses, bacteria, and parasites. Structural diversity in linkage types and modifications contributes to their functional specificity. They are important therapeutic targets, especially in the context of viral infections.
- Other names
- Sialylated GlycoconjugateSialoglycan ReceptorSialic Acid ReceptorSialo-glycoconjugate
02
Mechanism of action
Inhibition of viral binding or release by blocking sialic acid interactions. Lectins can also be used to target sialoglycans
03
Biological functions
Cell-cell interactionImmune modulationPathogen recognitionCell signaling
04
Disease associations
Infection
05
Safety considerations
Off-target effects of drugs targeting sialic acidPotential for altered immune responses
06
Interacting drugs
Neuraminidase inhibitors (e.g., Oseltamivir, Zanamivir)
2 more in the full profile.
07
Biomarkers
Sialic acid linkage type (α2,3 or α2,6) as predictor of host susceptibility to influenzaSialylation patterns in cancer
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