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Target intelligence / Profile preview
Sialidase (NA)
- Target
- NA
- Molecular classification
- Enzyme, Glycoside Hydrolase, GH33
01
Overview
Sialidases, also known as neuraminidases, are a family of glycoside hydrolase enzymes that catalyze the cleavage of terminal sialic acid residues from complex carbohydrates on glycoproteins and glycolipids. They are found in various organisms, including mammals, bacteria, and viruses. Mammalian sialidases (NEU1-4) regulate cell signaling, immune response, and lysosomal catabolism. Viral neuraminidases, like those in influenza viruses, are essential for viral release and are targets for antiviral drugs. Mutations in NEU1 cause Sialidosis, a lysosomal storage disorder.
- Other names
- NeuraminidaseAlpha-(2→3)-sialidase
02
Mechanism of action
Hydrolyzes terminal sialic acid residues from glycoconjugates; viral neuraminidase inhibitors block viral release.
03
Biological functions
Glycan remodelingImmune regulationPathogen interactionLysosomal catabolismCell signalingNutrient acquisition (bacteria)
04
Disease associations
SialidosisInfection (e.g., Influenza)Cancer metastasisNeurodegenerationLysosomal Storage Disorders
05
Safety considerations
Resistance to antiviral drugsOff-target effects of inhibitorsPotential for altered glycosylation patterns
06
Interacting drugs
Oseltamivir
3 more in the full profile.
07
Biomarkers
Sialic acid levelsNEU1 activity (in Sialidosis)Viral load (Influenza)
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