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Target intelligence / Profile preview
Sialoglycotope CA6 (CA6)
- Target
- CA6
- Molecular classification
- Carbohydrate antigen, Glycoepitope
01
Overview
Sialoglycotope CA6 is a tumor-associated carbohydrate antigen found on the Mucin-1 (MUC1) protein. It arises from aberrant glycosylation of MUC1 in cancer cells, specifically a sialic acid-dependent glycoepitope recognized by the monoclonal antibody DS6. CA6 is highly expressed in several carcinomas, including breast, ovarian, lung, bladder, pancreas, and cervix, making it an attractive target for cancer therapy.
- Other names
- MUC1-associated sialoglycanDS6 epitopeMUC1 CA6
02
Mechanism of action
Antibody-drug conjugate (ADC) mediated cytotoxicity
03
Biological functions
Cell surface protection (normal)Immune evasion (cancer)Metastasis (cancer)
04
Disease associations
Cancer
05
Safety considerations
On-target, off-tumor toxicityImmunogenicity of antibody
06
Interacting drugs
SAR566658
07
Biomarkers
CA6 expression level
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