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Target intelligence / Profile preview
Sialyl Lewis A (sLea)
- Target
- sLea
- Molecular classification
- Carbohydrate Antigen, Glycan, Tumor-associated carbohydrate antigen
01
Overview
Sialyl Lewis A (sLea), also known as CA19-9, is a tetrasaccharide carbohydrate antigen. It is structurally related to the Lewis blood group antigens and is best known for its role as a tumor-associated carbohydrate antigen, particularly in adenocarcinomas of the digestive tract such as pancreatic cancer. It acts as an epitope for selectins and is used clinically as a biomarker for gastrointestinal cancers. Antibodies targeting sLea have been developed for immunotherapy approaches against cancers expressing this antigen.
- Other names
- CA19-9 Antigen3-Sialyl LewisSialyl Lewis a
02
Mechanism of action
Antibodies targeting sLea can mediate tumor clearance through Fc-FcγR interactions.
03
Biological functions
Cell adhesionSelectin bindingLeukocyte traffickingEpitope presentation
04
Disease associations
CancerInflammation
05
Biomarkers
Diagnosis of gastrointestinal cancers (especially pancreatic cancer)Prognosis of gastrointestinal cancersMonitoring response to therapy for gastrointestinal cancers
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