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Target intelligence / Profile preview
Sialyl Lewis A epitope on Carbohydrate Antigen 19-9 (sLea/CA19-9)
- Target
- sLea/CA19-9
- Molecular classification
- Carbohydrate antigen, Glycan, Glycolipid/Glycoprotein component
01
Overview
Sialyl Lewis A (sLea) is a tetrasaccharide carbohydrate antigen, specifically the sialylated form of the Lewis^a antigen (CA19-9). It acts as a ligand for E-selectin and plays a role in cell adhesion and hematogenous metastasis, especially in cancer cells. It is widely used as a serum tumor marker, particularly for pancreatic cancer, but its utility is limited by false positives and negatives and its absence in Lewis antigen-negative individuals.
- Other names
- CA19-9Sialyl Lewis AsLeA
02
Mechanism of action
Antibodies targeting sLeA have been shown preclinically to mediate tumor clearance through immune mechanisms involving Fc-FcγR interactions.
03
Biological functions
Cell adhesionCell-cell recognitionE-selectin ligandHematogenous metastasis
04
Disease associations
CancerPancreatic cancerColorectal cancerCholestasisPancreatitisTumor progressionMetastasis
05
Safety considerations
False positives in benign diseasesFalse negatives in Lewis antigen-negative individuals (~10% of population)Not suitable for general cancer screening
06
Biomarkers
Pancreatic cancer diagnosisPancreatic cancer treatment response monitoringPancreatic cancer recurrence monitoringDistinguishing malignant vs. benign pancreatic masses
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