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Target intelligence / Profile preview
Sialyl Thomsen-nouveau Antigen (STn)
- Target
- STn
- Molecular classification
- Carbohydrate Antigen, Tumor-Associated Carbohydrate Antigen (TACA)
01
Overview
Sialyl Thomsen-nouveau Antigen (STn) is a carbohydrate antigen with the structure Neu5Ac(α2-6)GalNAc(α1-O)-Ser/Thr. It is rarely found in normal adult tissues but is abundantly expressed in more than 80% of human carcinomas, making it a tumor-associated carbohydrate antigen (TACA). STn plays a role in immune evasion and promotes tumor growth. It is a target for antibody-drug conjugates (ADCs) and other targeted therapies.
- Other names
- Sialyl-TnCD175s
02
Mechanism of action
Targeted drug delivery to STn-expressing cancer cells; Immunotherapy strategies that target STn-expressing cells
03
Biological functions
Immune EvasionTumor Growth PromotionSiglec Receptor Ligand
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects in tissues with low STn expressionImmune-related adverse events associated with antibody-based therapies
06
Interacting drugs
Antibody-Drug Conjugates (ADCs) targeting STn
07
Biomarkers
STn expression level in tumor tissue
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