SID1 transmembrane family member 2 (SIDT2)

SID1 transmembrane family member 2 (SIDT2) is a highly glycosylated lysosomal membrane protein implicated in the transport of RNA and DNA across the lysosomal membrane during nucleic acid autophagy, as well as in the hydrolysis of certain lipids[1][2][3]. SIDT2 has a structural core reminiscent of hydrolases in the CREST superfamily and forms a dimer with eleven transmembrane helices per protomer[1]. It acts as a putative nucleic acid transporter essential for lysosomal nucleic acid degradation, immune activation through antiviral cytokine production, and cellular metabolism of lipids and glucose[1][2][3]. SIDT2 is expressed in metabolically active tissues such as the liver, brain, and kidney, and its deficiency has been linked to metabolic, cardiovascular, inflammatory, and neurodegenerative disorders[1][3]. Although not a canonical drug target with approved therapeutics, it is of strong interest due to its fundamental roles in autophagy, immune response, and metabolism[1][2][3][6].

Other names

CGI-40PSEC0072UNQ685/PRO1325SIDT2SID1 transmembrane family member 2

Not established for drugs; functionally implicated in nucleic acid and lipid transport/hydrolysis, immune activation, and metabolic regulation[1][2][3].