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Target intelligence / Profile preview
Sigma non-opioid intracellular receptor 1
- Molecular classification
- Chaperone protein, Intracellular receptor
01
Overview
The sigma non-opioid intracellular receptor 1 (σ₁R) is a unique chaperone protein primarily located at the endoplasmic reticulum (ER) membrane. It is involved in regulating calcium and lipid signaling, modulating ion channels and neurotransmitter release, and influencing various cellular processes including cell proliferation, survival, learning, memory, and mood. Dysregulation of SIGMAR1 is implicated in several diseases, including neurological and psychiatric disorders, as well as cancer, making it an emerging therapeutic target.
- Other names
- Sigma–receptor type 1Sigma–type opioid receptorOPRS1SIGMA-RSigma–receptor
02
Mechanism of action
Allosteric modulation of associated proteins' functions; ligand-operated chaperone activity
03
Biological functions
Calcium signaling modulationLipid signaling modulationIon channel modulationNeurotransmitter release modulationCell proliferationCell survival/death regulationLearning and memoryMood regulationMitochondrial axonal transportCell stress response
04
Disease associations
SchizophreniaDepressionDistal hereditary motor neuronopathy type IIAmyotrophic lateral sclerosis (ALS16)Bipolar disorderSubstance abuse disordersCancerNeurodegenerative diseasesPsychiatric disorders
05
Safety considerations
Bell-shaped dose-response curves for σ₁ agonists (dose selection critical)Potential for psychotomimetic effects
06
Interacting drugs
Cocaine
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