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Target intelligence / Profile preview
Sigma Non-Opioid Intracellular Receptor 2 (Sigma-2 Receptor)
- Target
- Sigma-2 Receptor
- Molecular classification
- Receptor, Transmembrane protein, EXPERA domain protein
01
Overview
The sigma non-opioid intracellular receptor 2, or sigma‑2 receptor, is now recognized as TMEM97—a transmembrane EXPERA domain protein primarily located at the endoplasmic reticulum membrane. It plays roles distinct from those of its better-characterized counterpart, SIGMAR1/sigma‑1. Its elevated expression in cancer cells makes it an active area of research both as a therapeutic target and diagnostic marker.
- Other names
- Sigma 2 ReceptorSigma‑2 ReceptorTMEM97
02
Mechanism of action
Small-molecule modulators interact with this receptor for diagnostic and therapeutic purposes
03
Biological functions
Cellular localizationUnder investigation; implicated in cancer biology
04
Disease associations
Cancer
05
Biomarkers
Biomarker for proliferating cells
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