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Target intelligence / Profile preview
Sigma receptor 1 (S1R)
- Target
- S1R
- Molecular classification
- Receptor, Chaperone protein
01
Overview
The sigma-1 receptor (S1R), also known as sigma non-opioid intracellular receptor 1, is a unique ligand-operated chaperone protein primarily located at the endoplasmic reticulum (ER) membrane, especially in mitochondrial-associated membranes (MAMs). It modulates calcium signaling, lipid dynamics, and the cellular stress response by interacting with proteins such as GRP78/BiP and ion channels, GPCRs, kinases, and NMDA receptors. It has been implicated in neurological disorders, psychiatric conditions, drug dependence, cardiovascular function, and cancer.
- Other names
- Sigma-1 receptorSigma non-opioid intracellular receptor 1
02
Mechanism of action
Modulates calcium signaling, lipid dynamics, and cellular stress response through chaperone activity and interaction with various client proteins.
03
Biological functions
Calcium signaling modulationLipid dynamicsMolecular chaperone activityCellular stress response
04
Disease associations
Neurological disordersALS/frontotemporal dementiaAlzheimer's diseaseHuntington's diseasePsychiatric conditionsSchizophreniaDepressionDrug dependence/addiction mechanismsCardiovascular functionCancer
05
Safety considerations
Complex modulation mechanisms leading to bell-shaped dose-response curves.
06
Interacting drugs
(+)-Pentazocine
2 more in the full profile.
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