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Target intelligence / Profile preview
Sigma Receptor Binding Protein 1 (Sigma1R)
- Target
- Sigma1R
- Molecular classification
- Receptor, Chaperone protein, Transmembrane protein
01
Overview
The sigma-1 receptor (Sigma1R) is a unique ER-resident transmembrane protein that functions as a chaperone. It modulates calcium signaling, regulates ion channels, and is involved in various cellular processes, including cell proliferation, survival, and death. It has been implicated in neurological disorders, substance abuse, cancer, and cardiovascular function. It forms a trimeric structure and binds diverse ligands, including neuroactive steroids and synthetic compounds.
- Other names
- SRBP1Sigma-1 receptorS1Rσ₁RSIGMAR1 gene producthSigmaR1OPRS1SR31747-binding protein 1AAG8
02
Mechanism of action
Acts as an ER-resident chaperone, modulating calcium signaling, ion channels, and neurotransmitter release through interactions with various client proteins.
03
Biological functions
Calcium signaling modulationRegulation of ion channelsNeurotransmitter release modulationBDNF signaling pathwayEGF signaling pathwayCell proliferationCell survivalCell deathLipid transportMitochondrial axonal transportLearning processesMemory formationMood regulationProtection against oxidative stress
04
Disease associations
SchizophreniaDepressionBipolar disorderCocaine addictionCancer progressionCardiovascular dysfunctionCough
05
Safety considerations
Bell-shaped dose-response curves for agonists may complicate drug development.
06
Interacting drugs
(+)-pentazocine
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