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Target intelligence / Profile preview
Signal-induced proliferation-associated 1-like protein 1 (SIPA1L1)
- Target
- SIPA1L1
- Molecular classification
- Other (specifically, Rap/Ran GTPase-activating protein family), contains PDZ domain, Rap/Ran-GAP domain
01
Overview
Signal-induced proliferation-associated 1-like protein 1 (SIPA1L1) is a large cytoplasmic protein that acts as a GTPase-activating protein (GAP), particularly for RAP2A, and modulates synaptic function by regulating actin cytoskeleton organization and dendritic spine morphogenesis. It interacts with key synaptic proteins such as DLG4 and components of the ephrin receptor signaling pathway, and is implicated in neuronal morphology and synaptic plasticity. Variants in SIPA1L1 have been associated with certain cancers and autism spectrum disorder. Therapeutic targeting of SIPA1L1 has not yet been established[1][5][6][7].
- Other names
- E6TP1KIAA0440SPAR1SIPA1-like protein 1High-risk human papilloma virus E6 oncoproteins targeted protein 1Spine-associated RapGAP 1
02
Biological functions
GTPase activator activityActin filament bindingProtein kinase bindingRegulation of postsynapse organizationRegulation of dendritic spine morphogenesisEphrin receptor signalingRegulation of axonogenesis
03
Disease associations
Cancer (colorectal cancer, hereditary nonpolyposis type 7)Autism spectrum disorderNeurodevelopmental/neuropsychiatric disease (implicated due to synaptic function)
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