Signal peptidase 12kDa pseudogene (SPC12 pseudogene)

The signal peptidase 12kDa pseudogene is a genomic locus homologous to the functional SPC12 gene, which encodes a subunit of the signal peptidase enzyme complex involved in cleaving the signal peptides from nascent proteins in the endoplasmic reticulum[1][10]. However, as a pseudogene, ENSG00000236108 does not encode a functional protein and is generally considered non-coding. While some pseudogenes have been implicated in regulatory roles—such as acting as microRNA decoys or generating small regulatory RNAs—there is currently no direct evidence that this specific pseudogene, SPC12 pseudogene, is biologically active or clinically relevant[1][2][3][6][9]. Pseudogenes can, in principle, play indirect roles in cellular regulation or disease, but signal peptidase 12kDa pseudogene’s biological and clinical impact is not established[5][6][9]. This target is not misspelled, but as a pseudogene, it is not a canonical drug target or functional gene for therapeutic modulation. The "signal peptidase 12kDa pseudogene" should not be considered a receptor, enzyme, or transporter; it is best classified as a pseudogene, which may have limited or no biological activity[1][2][3][6][9].

Other names

SPC12 pseudogeneENSG00000236108LOC124904585