Signal peptide peptidase-like 3 pseudogene

This entry refers to a pseudogene annotated as "signal peptide peptidase-like 3 pseudogene" (also known as LOC100132647 and ENSG00000263733). It is not a protein-coding gene and does not produce a functional protein. As a result, it is not considered a valid biological or therapeutic target and has no established role in physiology, pathology, or medicine. This pseudogene designation distinguishes it from the functional gene "Signal peptide peptidase like 3" (SPPL3), which does encode an intramembrane-cleaving aspartyl protease involved in glycan modification and immune signaling. The pseudogene, however, does not produce active protein and thus does not share these properties or clinical relevance. Databases associate LOC100132647 only with pseudogene status, not with protein expression or biological function. The confusion can arise due to the near identity in name to SPPL3, a well-studied protein-coding gene, but LOC100132647 (ENSG00000263733) is definitively annotated as a pseudogene, not as the active enzyme.

Other names

LOC100132647ENSG00000263733signal peptide peptidase like 3 pseudogene