Signal recognition particle 19 kDa protein (SRP19)

Signal recognition particle 19 kDa protein (SRP19) is a highly conserved accessory protein component of the eukaryotic and archaeal signal recognition particle (SRP), a ribonucleoprotein complex fundamental for co-translational targeting of proteins to membranes[1][2][3]. SRP19 serves a crucial structural and assembly function by binding specifically to helix 6 of SRP RNA, promoting the correct folding and juxtaposition of SRP helices 6 and 8, which is a prerequisite for subsequent binding of SRP54 and maturation of a functional SRP complex[1][2][3]. SRP19 acts as a molecular scaffold and RNA-binding chaperone, but does not participate in direct recognition of signal sequences or catalysis; it is not classified as a drug target, receptor, enzyme, transporter, or transcription factor[1][2][3]. There are currently no known disease associations, interacting drugs, or biomarker or safety concerns linked to SRP19.

Other names

Signal recognition particle 19 kDa proteinSRP19signal recognition particle 19kDsignal recognition particle 19kDa