Signal recognition particle receptor subunit alpha (SRPRA)

Signal recognition particle receptor subunit alpha (SRPRA) is the peripheral membrane GTPase subunit of the signal recognition particle (SRP) receptor, a heterodimeric complex associated with the rough endoplasmic reticulum (ER) in eukaryotic cells[1][5]. This protein, together with its partner subunit SRP receptor beta (SRPRB), mediates the GTP-dependent targeting and docking of ribosome-nascent chain complexes—specifically those containing secretory or membrane proteins recognized by signal sequences—to the ER membrane via the SRP[1][2][3]. SRPRA interacts directly with the SRP54 subunit of the SRP and is necessary for the transfer of the nascent protein from SRP to the protein translocation apparatus (translocon) within the ER, thus playing a critical role in proper protein sorting and secretion[1][2][5]. Loss or dysfunction of SRPRA disrupts protein secretion, leads to defects in cell growth, and has been implicated in congenital neutropenia and related disorders[4][5].

Other names

Signal recognition particle receptor subunit alphaSRPRASRPRSR-alphaDP-alphaSRP-alphaSralphaDocking protein alphaDPsignal recognition particle receptor alpha subunitdocking protein alphasignal recognition particle receptor (docking protein)

Not directly drug-targeted; the primary mechanism is GTP-dependent interaction with SRP and mediation of protein translocation into the endoplasmic reticulum.