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Target intelligence / Profile preview
Signal Regulatory Protein Alpha (SIRPα)
- Target
- SIRPα
- Molecular classification
- Immunoglobulin superfamily, Transmembrane glycoprotein, Receptor
01
Overview
Signal regulatory protein alpha (SIRPα), also known as CD172a or SHPS-1, is a transmembrane glycoprotein and member of the SIRP family. It functions as an inhibitory receptor primarily expressed on myeloid cells, regulating innate immune responses. SIRPα interacts with CD47, delivering an inhibitory signal that suppresses phagocytosis.
- Other names
- CD172aSHPS-1
02
Mechanism of action
Inhibition of CD47-SIRPα interaction to promote phagocytosis
03
Biological functions
Immune regulationInhibition of phagocytosisRegulation of innate immunityCell signaling
04
Disease associations
CancerInflammation
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