Signal regulatory protein alpha pseudogene 1 (SIRPAP1)

Signal regulatory protein alpha pseudogene 1 (SIRPAP1) is a pseudogene, meaning it is a non-functional segment of DNA that resembles the functional SIRPA gene but does not produce a protein product. Pseudogenes such as SIRPAP1 are not translated into functional proteins and, consequently, do not serve as receptors, enzymes, transporters, or other typical therapeutic targets. Pseudogenes are generally classified as "genomic fossils"—sequences that resemble known genes but have lost their protein-coding ability or function, typically due to mutations. SIRPAP1 relates to the SIRPA gene, which encodes the functional signal regulatory protein alpha, a cell surface receptor involved in the regulation of immune cell activity. However, SIRPAP1 itself is not functional, making it irrelevant as a therapeutic target. This entry is often listed in genomic databases to annotate all discovered human DNA sequences, but therapeutic research and drug development focus on the protein-coding, functional relatives such as SIRPA—not the pseudogene SIRPAP1.

Other names

SIRPA2PSIRP alpha pseudogene 1