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Signal regulatory protein beta 1
- Molecular classification
- Receptor, Immunoglobulin superfamily, Signal-regulatory protein (SIRP) family, Transmembrane glycoprotein
01
Overview
Signal regulatory protein beta 1 (SIRPB1) is a transmembrane glycoprotein receptor belonging to the SIRP family. It is expressed on myeloid cells and, unlike SIRPA, activates signaling through association with the DAP12 adaptor protein, leading to myeloid cell activation. It does not bind CD47. It has been implicated in influencing inflammatory factor expression within the tumor microenvironment and modulating microglial response in Alzheimer's disease models.
- Other names
- CD172bSIRP-BETA-1CD172 antigen-like family member B
02
Biological functions
Immune responseSignal transductionMyeloid cell activationNegative regulation of receptor tyrosine kinase-coupled signalingPhagocytosis
03
Disease associations
InflammationNeurodegenerative diseaseCancer
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