Signal sequence receptor subunit 3 (SSR3)

SSR3, also known as TRAP-gamma, is a subunit of the signal sequence receptor complex (SSR), which is a component of the translocon-associated protein (TRAP) complex. This endoplasmic reticulum membrane protein plays crucial roles in protein translocation across the ER membrane, integration of nascent polypeptides into the ER, and regulation of signal sequence recognition. It is also involved in transmembrane helix insertion, modulation of ER stress responses, regulation of glycoprotein biosynthesis, and calcium binding. Dysfunction of SSR3 has been implicated in various diseases, including congenital disorders of glycosylation, a severe early-onset progressive encephalopathy syndrome, and certain cancers like hepatocellular carcinoma, suggesting its potential as a therapeutic target.

Other names

Translocon-associated protein subunit gammaTRAP-gammaSignal sequence receptor subunit gammaTRAPGSSR-gammaTRAP-complex gamma subunit