Target intelligence / Profile preview

Signal Transducer and Activator of Transcription 1 (STAT1)

Target: STAT1
Molecular classification: Transcription factor

Overview

Signal transducer and activator of transcription 1 (STAT1) is a critical transcription factor that mediates cellular responses to various cytokines, most notably interferons (IFNs). It plays a central role in immune response regulation, cell viability, proliferation, apoptosis, and differentiation. Mutations can lead to altered immune function and susceptibility to infections or chronic mucocutaneous candidiasis.

Biological functions

Signal transductionImmune responseCell proliferationApoptosisCell viabilityDifferentiationAntiviral defense

Disease associations

CancerInfectionChronic mucocutaneous candidiasis

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