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Signal Transducer and Activator of Transcription 3 (STAT3)
- Target
- STAT3
- Molecular classification
- Transcription factor
01
Overview
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that regulates gene expression involved in cell growth, survival, differentiation, and immune responses. It is activated by cytokines and growth factors, and dysregulation of STAT3 is implicated in various diseases including cancer and immune disorders.
- Other names
- Acute-phase response factorAPRF
02
Mechanism of action
STAT3 inhibitors (small molecules, oligonucleotides) aim to block STAT3 phosphorylation, dimerization, DNA-binding, or transcriptional activity.
03
Biological functions
Signal transductionCell proliferationApoptosisImmune responseCell migrationCell differentiationGene expression regulation
04
Disease associations
CancerAutosomal Dominant Hyper-IgE Syndrome (AD-HIES)Autoimmune diseasesMetabolic disordersViral infectionsInflammation
05
Safety considerations
Potential for broad effects on immune functionOff-target effects due to sequence homology with other STAT family membersDevelopment of resistance mechanismsBone/teeth/blood vessel abnormalities (AD-HIES)
06
Biomarkers
STAT3 phosphorylation levels (Y705, S727)STAT3 protein expressionExpression of STAT3 target genes
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