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Target intelligence / Profile preview
Signal Transducer and Activator of Transcription Protein Family (STAT)
- Target
- STAT
- Molecular classification
- Transcription factor
01
Overview
The STAT protein family consists of intracellular transcription factors that mediate cellular immunity, proliferation, apoptosis, and differentiation. They are activated by JAKs upon cytokine/growth factor stimulation, translocate to the nucleus, and regulate gene expression. There are seven mammalian STAT proteins (STAT1, 2, 3, 4, 5A, 5B, 6). Persistent activation is linked to cancer, while some STATs act as tumor suppressors. They interact with JAKs and other transcription factors like p53/NF-kB.
- Other names
- STAT proteinsSTAT transcription factors
02
Mechanism of action
Inhibition of STAT phosphorylation, dimerization, or DNA binding.
03
Biological functions
Signal transductionImmune responseCell proliferationApoptosisCell differentiationRegulation of gene expression
04
Disease associations
CancerInflammationAutoimmune diseasesImmunodeficiencyOther
05
Safety considerations
Potential for immune suppressionOff-target effects on other signaling pathways
06
Biomarkers
STAT expression levelsSTAT phosphorylation status
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