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Target intelligence / Profile preview
Signaling lymphocyte activation molecule family member 5 (SLAMF5)
- Target
- SLAMF5
- Molecular classification
- Type I transmembrane glycoprotein, SLAM/CD150 subfamily, CD2 family, Receptor
01
Overview
Signaling lymphocyte activation molecule family member 5 (SLAMF5), also known as CD84, is a cell surface receptor belonging to the SLAM (CD150) subfamily of the CD2 family within the immunoglobulin superfamily. It plays a significant role in regulating both innate and adaptive immune responses through its function as an adhesion and signaling molecule. It is broadly expressed across most hematopoietic cells and modulates activation, differentiation, proliferation, and cytotoxicity of various leukocyte subsets. Altered expression or genetic variants are linked to autoimmune diseases and cancer.
- Other names
- CD84
02
Mechanism of action
Homophilic binding; recruitment of SAP/EAT-2 adaptors; modulation of signaling pathways involved in immune cell activation, differentiation, proliferation, and cytotoxicity.
03
Biological functions
AdhesionCo-stimulationImmune modulationSignal transductionRegulation of cytokine productionRegulation of autophagyCell-cell interactions
04
Disease associations
Autoimmune diseases (Systemic Lupus Erythematosus, Rheumatoid Arthritis)Cancer (Chronic Lymphocytic Leukemia)Inflammation
05
Biomarkers
Emerging biomarker for inflammatory autoimmune disordersEmerging biomarker for certain cancers
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