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Target intelligence / Profile preview
Signaling Lymphocytic Activation Molecule (SLAM)
- Target
- SLAM
- Molecular classification
- Cell surface glycoprotein, Receptor, Immunoglobulin superfamily
01
Overview
Signaling Lymphocytic Activation Molecule (SLAM) is a glycoprotein belonging to the immunoglobulin superfamily expressed on T cells, B cells, and thymocytes. Engagement of SLAM enhances antigen-specific proliferation and cytokine production by CD4+ T cells, particularly IFN-γ, independent of CD28 co-stimulation. This suggests a novel pathway for potentiating T-cell expansion and promoting a Th0/Th1 cytokine profile.
02
Mechanism of action
Enhances T cell proliferation and cytokine production independent of CD28
03
Biological functions
T cell activationCo-stimulationCytokine productionImmune response
04
Disease associations
InflammationInfectionAutoimmunity
05
Safety considerations
Potential for immune dysregulationRisk of autoimmunity
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