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Target intelligence / Profile preview
Silent information regulator protein homolog 1 (SIRT1)
- Target
- SIRT1
- Molecular classification
- Enzyme, Histone modification, Transcription factor, Sirtuin, NAD+-dependent deacetylase
01
Overview
Silent information regulator protein homolog 1 (SIRT1) is an NAD+-dependent deacetylase that regulates gene expression by removing acetyl groups from histones and non-histone proteins. It plays diverse roles in cellular physiology, including regulation of cell proliferation, differentiation, metabolism, energy homeostasis, stress response, aging processes, and cancer biology. SIRT1 is ubiquitously expressed across tissues but has particularly important roles in the liver, pancreas, and brain.
- Other names
- hSIR2hSIR2LRegulatory protein SIR2 homolog 1NAD-dependent protein deacetylase sirtuin‑1
02
Mechanism of action
NAD+-dependent lysine deacetylation of histones and non-histone proteins, modulating gene expression.
03
Biological functions
Epigenetic regulationMetabolic sensingStress response modulationInflammation suppressionAging/longevityCell proliferationCell differentiationEnergy homeostasisDNA repairCircadian rhythm
04
Disease associations
Rheumatoid arthritisSystemic sclerosisVasculitisCancerAging-related diseasesFatty liver diseaseDiabetes mellitus type II/insulin resistance syndromesNeurodegenerative disorders
05
Safety considerations
Potential for off-target effects due to broad substrate specificity.Role in cancer is complex and context-dependent, with both tumor-suppressing and tumor-promoting activities reported.
06
Interacting drugs
Resveratrol
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