Silicon-related pathways

"Silicon-related pathways" describe a group of biological processes and molecules involved in the uptake, transport, and functional implementation of silicon in living organisms, especially plants and, to a lesser extent, mammals. In plants, key silicon transporters such as Lsi1, Lsi2, and Lsi6 mediate the uptake and distribution of silicon, which modulates stress responses, enhances resistance to pathogens and herbivores, and strengthens mechanical properties[2][3][4][6][7]. Silicon affects signaling pathways including phytohormonal (e.g., jasmonic acid in defense), oxidative stress (ROS), and sometimes direct modulation of immune recognition or stress response[3][6]. In mammals, silicon can influence bone formation/remodeling and can impact cellular signaling (e.g., via the RANK/RANKL/OPG pathway)[5]. Exposure to synthetic silica nanoparticles can activate toxicity pathways (TNF, MAPK) across diverse cell types and is associated with safety concerns in biomedical and industrial contexts[1]. Overall, "Silicon-related pathways" covers integrative physiological responses much more than a single molecular target, and is not considered a canonical druggable receptor, enzyme, or protein target.

Other names

Silicon signalingSilicon uptake/transport pathwaysSilicon defense pathwaysSilica-induced signaling