SIN3 transcription regulator family member B (SIN3B)

SIN3 transcription regulator family member B (SIN3B) is a master transcriptional scaffold protein that organizes histone deacetylase (HDAC) complexes, mediating chromatin remodeling and transcriptional repression. It acts by binding, stabilizing, and activating Class I HDACs via direct protein–protein interactions, serving as a core component that enables gene silencing through targeted histone deacetylation, with the complex preferring to deacetylate histone H3 at lysine 27 (H3K27ac), among other sites. SIN3B interacts with various transcription factors and is pivotal in cell fate decisions such as cell cycle exit, senescence, and differentiation. Its loss or dysregulation is implicated in cancer biology—where it can act as a tumor suppressor or promote metastasis depending on context—and in some neurodevelopmental syndromes. As a molecular scaffold and regulator within chromatin remodeling complexes, SIN3B is a key node integrating oncogenic, developmental, and inflammatory signals to control gene expression

Other names

SIN3BPaired amphipathic helix protein Sin3bKIAA0700Histone deacetylase complex subunit Sin3bTranscriptional corepressor Sin3bSIN3 homolog Btranscriptional regulator Sin3bpaired amphipathic helix protein Sin3b

Drugs modulate the activity of the SIN3B-containing histone deacetylase complex, primarily by inhibiting the associated HDAC enzyme (Class I HDACs, especially HDAC1/2) leading to increased acetylation of histones and derepression of gene transcription