Sin3A-associated protein 130 (SAP130)

Sin3A-associated protein 130 (SAP130) is a core subunit of the histone deacetylase-dependent SIN3A corepressor complex, where it acts as a scaffold and regulatory partner facilitating chromatin remodeling and transcriptional repression through histone and non-histone protein deacetylation. SAP130 binds both the SIN3A scaffold and HDAC1 enzyme within this multi-protein complex and helps stabilize its repressive functions on target genes. It plays a crucial role in epigenetic gene regulation, with evidence from animal models implicating it in heart development and demonstrating that its loss can cause severe developmental syndromes such as hypoplastic left heart syndrome. SAP130 is not a spliceosomal protein (in contrast to the similarly named SF3B3, which was formerly called "spliceosome-associated protein 130" and is a source of literature confusion). SAP130 itself is not a direct drug target or therapeutic biomarker and is considered essential for embryonic development and tissue homeostasis.

Other names

SAP130Sin3A associated protein 130Histone deacetylase complex subunit SAP130130 kDa Sin3-associated polypeptideSin3-associated polypeptide p130Sin3A associated protein 130kDaSAP130phSAP130A0A2R8YDB8C9J683

Not applicable; SAP130 is not directly targeted by drugs.