Sin3A associated protein 25 (SAP25)

Sin3A associated protein 25 (SAP25) is a protein subunit of the Sin3A/HDAC transcriptional corepressor complex, involved predominantly in the negative regulation of gene expression through chromatin remodeling and histone deacetylation[1][2][6]. SAP25 acts as an adaptor protein, interacting with multiple protein complexes such as deubiquitinases (USP11), E3 ubiquitin ligases (SCF(FBXO3)), O-linked N-acetylglucosamine transferase (OGT), and TET methylcytosine dioxygenases, in addition to core Sin3/HDAC complex members[2]. These interactions enable SAP25 and the Sin3/HDAC complex to precisely control gene expression, particularly in the context of the immune response and potentially in neurodevelopmental processes[1][2]. There is currently no direct evidence that SAP25 is a drug target, nor are drugs, biomarkers, or safety concerns associated directly with SAP25 established in the literature[1][2][6].

Other names

Histone deacetylase complex subunit SAP25Sin3 corepressor complex subunit SAP2525 kDa Sin3-associated polypeptideSin3A-associated protein, 25kDaFLJ00248Sin3-associated polypeptide, 25kDaSin3A-binding protein 25