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Sinapis alba extract

Molecular classification
Plant extract, Phytochemical mixture, Glucosinolate-containing extract
01

Overview

Sinapis alba extract, commonly known as white mustard extract, is a complex phytochemical mixture derived from the seeds of the Sinapis alba plant rather than a singular therapeutic target molecule. Its primary bioactive profile includes the glucosinolate sinalbin, which undergoes enzymatic conversion by myrosinase into p-hydroxybenzyl isothiocyanate when exposed to moisture [1][2]. Traditionally, this extract is utilized in topical applications as a rubefacient and counter-irritant to alleviate muscular pain and respiratory congestion by inducing localized vasodilation [3][4]. At a molecular level, its components have been investigated for their ability to exert antimicrobial and antioxidant effects, potentially through the modulation of oxidative stress response elements like Nrf2 [1][5]. Because it is a crude botanical extract containing multiple chemical species, it does not possess a canonical protein target and is instead characterized by its broad multi-target pharmacological activity [2][3].

Other names
White mustard extractBrassica alba extractMustard seed extractSemen Erucae
02

Mechanism of action

Exerts therapeutic effects primarily through its bioactive glucosinolate, sinalbin, which is hydrolyzed by the endogenous enzyme myrosinase into p-hydroxybenzyl isothiocyanate; this compound acts as a local irritant (rubefacient) to stimulate blood flow and may modulate Nrf2 and inflammatory cytokine pathways.

03

Biological functions

AntimicrobialAntioxidantAnti-inflammatoryDigestive stimulationRubefacient
04

Disease associations

InflammationDyspepsiaRheumatismRespiratory congestionSkin irritation
05

Safety considerations

Skin irritation and vesication (blistering) upon prolonged contactPotential goitrogenic effects with high systemic intakeAllergic reactions (Mustard allergy)Gastrointestinal irritation if ingested in high concentrations
06

Biomarkers

Sinalbin contentp-Hydroxybenzyl isothiocyanate levelsMyrosinase activity

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