Sine oculis-binding protein homolog (SOBP)

Sine oculis-binding protein homolog (SOBP) is a nuclear zinc finger protein encoded by the SOBP gene found on human chromosome 6q21[1][3]. It is implicated in the development of the cochlea (inner ear), as well as broader neural and sensory organ development, particularly based on conservation across species including Drosophila and vertebrates[1][2]. In humans, mutations in SOBP cause an autosomal recessive syndrome (MRAMS), which involves intellectual disability, maxillary protrusion, and strabismus[1][3]. In mice, loss of function leads to hearing loss and abnormal behavior (circling), associated with anatomical defects in the cochlea[1]. SOBP contains conserved motifs found in FCS-type zinc finger domains, suggesting a role in gene regulation, but it is not classified as a classic transcription factor or as a common drug target[1][3].

Other names

SOBPJackson circler protein 1JXC1MRAMSFLJ10159