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Target intelligence / Profile preview
Single-strand-selective monofunctional uracil-DNA glycosylase (SMUG1)
- Target
- SMUG1
- Molecular classification
- Enzyme, DNA glycosylase
01
Overview
Single-strand-selective monofunctional uracil-DNA glycosylase (SMUG1) is an enzyme encoded by the SMUG1 gene in humans. It acts as a DNA glycosylase within the base excision repair (BER) pathway, specifically removing uracil residues from both single-stranded and double-stranded DNA, as well as excising certain pyrimidine oxidation products such as 5-hydroxymethyluracil. SMUG1 operates primarily to prevent mutations caused by cytosine deamination or the incorporation of uracil into DNA, thereby maintaining genome stability. In vertebrates, it functions as a backup to uracil-DNA glycosylase (UNG), particularly under conditions when UNG is absent or deficient. SMUG1 has also been implicated in regulating the expression of specific genes and may play a role in immune function and cancer, depending on the integrity of DNA repair pathways[1][2][3][4][5][6].
- Other names
- Single-strand selective monofunctional uracil DNA glycosylaseUNG3FDGHMUDG
02
Mechanism of action
Uracil excision from single- and double-stranded DNA as part of the base excision repair pathway
03
Biological functions
Base excision repairRemoval of uracil from DNARemoval of oxidized pyrimidines (e.g., 5-hydroxymethyluracil)Maintenance of genome stability
04
Disease associations
Cancer (implicated via DNA repair pathway disruption)Immune response (e.g., antibody gene diversification)Other (potential involvement in neurobiology and gene regulation)
05
Safety considerations
Potential impact on genome stability if inhibited or deficient
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