Singlet Oxygen Generation via Photoactivation (None)

Singlet oxygen generation via photoactivation is a photochemical process used in photodynamic therapy (PDT) to treat cancer. A photosensitizer absorbs light and transfers energy to molecular oxygen, converting it to highly reactive singlet oxygen. This reactive species induces oxidative damage, leading to tumor cell death, vascular disruption, and immune response activation. The selectivity of PDT arises from preferential accumulation of the photosensitizer in tumor tissue and localized light delivery. A key mechanism involves singlet oxygen-mediated inactivation of catalase on tumor cell membranes, reactivating ROS-mediated apoptotic pathways.

Other names

Photodynamic Therapy (PDT)^1O_2 GenerationPhotoactivated Singlet Oxygen Production

Photosensitized energy transfer from activated dye/sensitizer to molecular oxygen, generating singlet oxygen that induces oxidative damage and selective cancer cell death.