Sirtuin 2 (None)

Sirtuin 2 (SIRT2) is a member of the sirtuin family of proteins, which are NAD+-dependent deacetylases and ADP-ribosyltransferases. It plays roles in cellular regulation, metabolism, aging, and disease. It is primarily cytosolic but also found in the nucleus during certain cell cycle phases. SIRT2 exerts multiple regulatory functions, including NAD+-dependent lysine deacetylase activity and mono ADP-ribosyltransferase activity. It regulates microtubule dynamics, myelination control, gluconeogenesis, chromatin compaction, and DNA damage response. SIRT2 modulates autophagy/mitophagy and is implicated as both a tumor suppressor or promoter depending on context. It is a potential therapeutic target for age-related disorders including cancer/metabolic syndrome/neurodegeneration.

Binding NAD+ at its catalytic core, deacetylating substrate lysines via an ADPR peptidyl-imidate intermediate, and releasing nicotinamide from NAD+, transferring acetyl group from substrate to form O-acetyl ADP ribose plus deacetylated protein product.