Sirtuin 2-7 (SIRT2-7)

Sirtuin 2-7 (SIRT2-7) refers to a group of six mammalian sirtuins (SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, and SIRT7) that belong to the sirtuin family of NAD+-dependent deacylases (1, 2). These enzymes are characterized by a conserved catalytic core and are localized to distinct cellular compartments: SIRT2 is primarily cytoplasmic; SIRT3, SIRT4, and SIRT5 are mitochondrial; and SIRT6 and SIRT7 are nuclear or nucleolar (2, 8). They regulate a wide array of biological processes, including metabolism, DNA repair, cell cycle progression, and stress responses, by removing acetyl, succinyl, malonyl, or other acyl groups from both histone and non-histone protein substrates (1, 16, 27). Due to their central roles in cellular homeostasis, SIRT2-7 are implicated in the pathogenesis of various diseases, such as cancer, neurodegenerative disorders (e.g., Parkinson's and Alzheimer's), and metabolic syndromes (3, 9, 11). Therapeutic strategies targeting these sirtuins involve the development of both small-molecule inhibitors and activators, though the context-dependent nature of their functions—acting as either tumor suppressors or promoters—poses significant challenges for clinical application (10, 15, 22).

Other names

Sirtuin family members 2-7SIR2-like proteins 2-7Class III histone deacetylases 2-7NAD-dependent protein deacetylases 2-7

NAD+-dependent deacetylation and deacylation of histone and non-histone proteins