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Sirtuin Pathway (None)
- Target
- None
- Molecular classification
- Enzyme family, Class III HDACs
01
Overview
The sirtuin pathway refers to a family of NAD+-dependent enzymes (sirtuins, SIRT1–SIRT7 in mammals) that regulate a wide range of cellular processes through deacetylation and ADP-ribosylation of target proteins. Sirtuins are highly conserved across species and play critical roles in metabolism, aging, stress resistance, DNA repair, apoptosis, inflammation, mitochondrial function, and circadian regulation.
- Other names
- SIRT pathwaySilent information regulator 1 pathway
02
Mechanism of action
Activation enhances DNA repair, promotes mitochondrial biogenesis, reduces oxidative damage and inflammation, and modulates apoptosis.
03
Biological functions
Metabolism regulationDNA repairApoptosis regulationStress resistanceInflammation modulationMitochondrial functionCircadian regulationGene expression regulationCellular stress responseDeacetylation/ADP-ribosylation
04
Disease associations
AgingNeurodegenerative diseaseAlzheimer’s diseaseCardiovascular diseaseMetabolic syndromeDiabetes mellitus type II
05
Safety considerations
Off-target effectsContext-dependent effects on apoptosisPotential for unknown long-term effects
06
Interacting drugs
Resveratrol
4 more in the full profile.
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