Sister chromatid cohesion protein PDS5 homolog B (PDS5B)

Sister chromatid cohesion protein PDS5 homolog B (PDS5B) is a conserved regulatory protein that associates with the cohesin complex, which is essential for holding sister chromatids together to ensure accurate chromosome segregation during mitosis and meiosis[4][2][3]. Beyond its cohesin-related functions, PDS5B plays roles in DNA repair, gene transcription regulation, and DNA replication, and is involved in cell cycle control and cell proliferation—in particular, it mediates androgen-induced growth arrest in prostate epithelial cells[4][3][2]. There are two vertebrate paralogs, PDS5A and PDS5B, with both redundant and unique roles. Loss or mutation of PDS5B has been implicated in various developmental disorders, such as Cornelia de Lange syndrome, and in cancer, where its potential tumor-suppressor function is of interest. Knockout animal models show multiple congenital defects and early lethality, underscoring its essential role in development[2]. Structurally, PDS5B contains HEAT repeats that mediate protein-protein interactions, and it localizes predominantly to the nucleus, particularly the nucleolus[2][1].

Other names

APRINAS3KIAA0979FLJ23236CG008Androgen-induced proliferation inhibitorAndrogen-induced prostate proliferative shutoff-associated protein AS3androgen induced inhibitor of proliferationandrogen-induced shutoff 3