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Target intelligence / Profile preview
Six-Transmembrane Epithelial Antigen of Prostate 2 (STEAP2)
- Target
- STEAP2
- Molecular classification
- STEAP Family, Metalloreductase, Transmembrane Protein
01
Overview
Six-transmembrane epithelial antigen of prostate 2 (STEAP2) is a member of the STEAP family, functioning primarily as a metalloreductase involved in metal ion reduction and transport. It is overexpressed in various cancers, particularly prostate cancer, contributing to tumor progression through effects on cell proliferation, migration, apoptosis resistance, and therapeutic resistance. It also plays a role in modulating inflammation and is involved in several metabolic pathways.
- Other names
- STAMP1Six Transmembrane Protein of Prostate 1
02
Biological functions
Metal ion reduction (iron/copper)Molecular transportCell cyclingImmune response modulationOxidative stress regulationInflammation controlFatty acid metabolismGlucose metabolism
03
Disease associations
Cancer progression/metastasisInflammation
04
Safety considerations
Therapeutic resistance mechanisms
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