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Target intelligence / Profile preview
Six Transmembrane Epithelial Antigen of the Prostate 1 (STEAP1)
- Target
- STEAP1
- Molecular classification
- Integral membrane protein, Six transmembrane protein, Metalloreductase-related protein family
01
Overview
STEAP1 is a cell surface antigen and integral membrane protein belonging to the STEAP family. It is characterized by six transmembrane α-helices and is predominantly expressed at cell-cell junctions. Unlike other members, STEAP1 lacks an intracellular NADPH-binding domain and does not function as a classical metalloreductase. It is highly upregulated in several human cancers, particularly prostate cancer, making it a promising therapeutic target. Knockdown studies show its role promoting tumor growth through proliferation pathways. Monoclonal antibodies against STEAP1 inhibit tumor growth.
02
Mechanism of action
Monoclonal antibodies inhibit tumor growth; knockdown leads to G1 cell cycle arrest, suppression of c-Myc signaling and increased apoptosis.
03
Biological functions
Cell proliferationApoptosis regulationCell cycle regulationHeme cofactor bindingPotential Fe³⁺ reduction (in heterotrimers)
04
Disease associations
CancerProstate CancerLiver Cancer
05
Safety considerations
Potential off-target effects due to limited expression in normal tissues (needs further investigation)
06
Interacting drugs
Monoclonal antibodies against STEAP1
1 more in the full profile.
07
Biomarkers
STEAP1 expression in prostate tissue (diagnosis/monitoring)Circulating STEAP1-positive extracellular vesicles (diagnosis)
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